Toehold Switch Optimization Service
The toehold switch has advanced biosynthesis as a tool for manipulating gene expression and has also contributed to several research areas such as diagnostic development, disease research, and gene-targeting therapies. However, you need to know that a substandard toehold switch may not only be ineffective but also misleading to your research. Toehold switch design requires consideration of sequence uniqueness, length, and structure of the trigger RNA (also known as target RNA), among other issues. Therefore, your direct prediction of the toehold switch using toehold switch design software may not be accurate. In view of this, it is necessary for you to choose the optimization service of CD BioSciences.
Our Services
At CD BioSciences, we combine different deep machine learning models with toehold switch, using toehold switch of multiple genes to continuously train to predict the most accurate toehold switch for different trigger RNAs. We are fully confident that we can provide you with toehold switch optimization services through our continuous improvement and refinement of our technology platform. We are able to optimize your designed switch sequence based on your trigger RNA sequence.
First, we will use the model we build to treat your toehold switch sequence as a one-dimensional image or line of nucleotide bases, identify patterns of bases and potential interactions between those bases, and predict good and poor toehold sequences. Then, based on this, different learning models are used to provide you with the appropriate toehold switch optimization according to your research objectives. Providing you with biological tools that perform specific functions and are complex, and also creating toehold switches designed to detect specific pathogenic RNA sequences that can be used to develop new diagnostic tests.
Our Advantages
- Our optimized toehold switches do not suffer from off-target effects, etc.
- We have an advanced toehold switches technology platform and a professional research team.
- We have provided toehold switch optimization services to the satisfaction of many customers.
- We use a variety of machine models to optimize the toehold switch sequence to ensure that we provide you with the most suitable toehold switch.
We Are Ready to Provide
CD BioSciences is constantly upgrading its strengths, updating relevant technologies, and learning the latest knowledge to provide you with quality toehold switch optimization services. We are here for you 24 hours a day, if you are interested in this service, please feel free to contact us.
References
- Valeri, J.A.; et al. Sequence-to-function deep learning frameworks for engineered riboregulators. Nat Commun. 2020, 11(1): 5058.
- Angenent-Mari, N.M.; et al. A deep learning approach to programmable RNA switches. Nat Commun. 2020, 11(1): 5057.